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Polynucleotides are a relatively new type of anti-ageing injectable that can be used to rejuvenate the face, neck, decolletage and hands.
Polynucleotides do not artificially pump up the skin, they work to restore the natural volume that gets lost as a result of declining collagen and elastin.

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at a glance

Treatment Overview

What to expect from this treatment…

Expected Results

Youthful, Radiant Skin

Treatment time

30 Minutes


Topical Anaesthetic


Up to 24 Hours

Session Frequency

9-12 Months

Award Winning


This treatment is often referred to as a skin boosting procedure. At Ambra Clinic we use brands including: Plenhyage, Croma PhilArt and Lumieyes which contain high concentrations of moisturising ingredients, and are known for creating natural volume beneath the surface of the skin.

As an effective bio-stimulator, these innovative products will trigger the production of new collagen and elastin when injected beneath the skin, and increase the number of fibroblasts.

But, in addition to skin boosters, polynucleotides will also provide nourishment to the inner structure - effectively feeding the skin.

By building the extracellular matrix (the intricate network of skin cells and tissues), we can slow down the rate at which collagen, elastin and hyaluronic acid breaks down, and the development of facial wrinkles and lax skin.

Polynucleotides are bioploymers which are made from stretchy molecules extracted from fragments of fish DNA. They contain naturally occurring biomolecules which have greater compatibility with the integral fabrication of the skin, making them a highly effective healing / restorative product.

For best results our trained practitioner may recommend 2 treatment sessions, performed 2-4 weeks apart.

Like other skin boosters, the outcome of a polynucleotide treatment will develop gradually over 2-3 months as the new fibrous tissue regenerates. And, as the ageing process will continue we recommend top-up procedures every 9-12 months to maintain your radiant, youthful look.



Many people are found to be suitable for polynucleotide treatment. However, if you are allergic to fish, dermal fillers may be a less risky option (unless another skin boosting product is suggested).


By carrying out a thorough consultation we will determine whether the treatment is both suitable and safe for you to undergo. Treatments that induce a natural restorative response are often found to be safer, and we can combine the use of polynucleotides with other aesthetic procedures.


Ambra Clinic takes every step to ensure you are comfortable throughout any treatment we perform. For an injectable procedure we use very fine needles and offer the use of a topical anaesthetic to minimise any potential discomfort.


An injectable treatment is likely to incur some minor side effects, including: redness, slight swelling, small bumps at the point of injection and tiny puncture marks. These effects will disappear over some hours, with any bruising fading within a few days. After 48 hours, any marks can be concealed using make-up.


Although you should be able to continue with your day, many patients decide to have 24 hours of social downtime to allow for any redness and swelling to subside. We would recommend that you avoid touching or rubbing the treated area for up to 48 hours to avoid further irritation, and to allow the product to settle beneath the skin.


At Ambra Clinic our polynucleotide treatments are available from £120

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Treatment starting from £120

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What our clients say

Client reviews

Used Dr Maryam McMillan for a few years now. She is AMAZING. Would not trust anyone else with my face now. So happy. Feel the most confident I’ve ever felt. Prices are good and service even better x

Five stars Callie Jayne 5 months ago

I went to see Dr McMillan for the first time about a year ago so she could revise some badly done under eye filler NOT DONE BY DR MCMILLAN, and she’s done the most fantastic job i had terrible anxiety from the previous injector and was very nervous, I did so much research but decided to go ahead with Dr McMillan as she was so reassuring and honest with it all

Five stars Mel 5 months ago

Having visited many clinics across the world, Ambra Aesthetic provides the highest in skin care. The staff are incredibly professional & knowledgeable. They always tailor the treatments according to your skin type. They are the best.

Five stars Alice Katz 2 months ago

I would highly recommend Maryam and her team at Ambra Aesthetic clinic, my husband had dental treatment with straightening and whitening of his teeth and the results are amazing. I have also had various treatments and we are both very pleased with the service, kindness shown and professionalism. Thank you Ambra. See you soon.

Five stars Liza Pluto 2 months ago

Ambra Aesthetics are the place to go to for professional, friendly service. You don’t need to go to Harley Street. Dr M and her team are all experts and really take care of you giving the best treatments and advice. Sam on the front desk is a dream. In lots of places the staff can look scary from doing too much but Ambra you can tell it’s all about discrete subtle tweakments. . Don’t hesitate to go!

Five stars Dan 2 months ago

Such friendly, professional service! Dr Maryam is brilliant and everyone at the clinic is so helpful. Ambra is excellent at Profilho, dermal fillers and Hydrafacial. It is like a top Central London aesthetic clinic on your doorstep – only with easy parking and lovely people!

Five stars Sue Cipin 2 months ago